Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research

J Med Chem. 2011 May 12;54(9):3109-52. doi: 10.1021/jm100809g. Epub 2011 Apr 19.
No abstract available

MeSH terms

  • Animals
  • Carnitine / analogs & derivatives
  • Carnitine / pharmacology
  • Carnitine / therapeutic use
  • Carnitine O-Palmitoyltransferase / antagonists & inhibitors
  • Carnitine O-Palmitoyltransferase / deficiency
  • Carnitine O-Palmitoyltransferase / metabolism*
  • Catalytic Domain
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / metabolism
  • Energy Metabolism / drug effects*
  • Enzyme Activators / pharmacology
  • Enzyme Activators / therapeutic use
  • Ethylene Oxide / analogs & derivatives
  • Ethylene Oxide / pharmacology
  • Ethylene Oxide / therapeutic use
  • Heart Failure / drug therapy
  • Heart Failure / metabolism
  • Humans
  • Insulin Resistance
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / deficiency
  • Isoenzymes / metabolism
  • Lipid Metabolism / drug effects
  • Myocardial Ischemia / drug therapy
  • Myocardial Ischemia / metabolism
  • Organ Specificity
  • Protein Conformation
  • Sequence Homology, Amino Acid
  • Stereoisomerism

Substances

  • Enzyme Activators
  • Isoenzymes
  • Carnitine O-Palmitoyltransferase
  • Ethylene Oxide
  • Carnitine